Cardiology Division, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Yawkey 5B, Boston, MA 02114, USA avkhera@mgh.harvard.edu rader@mail.med.upenn.edu. Department of Medicine and Cardiovascular Institute, Perelman School of Medicine, Philadelphia, PA, USA. Cardiovascular Unit, Eli Lilly and Company, Indiannapolis, IN, USA. Department of Medicine and Cardiovascular Institute, Perelman School of Medicine, Philadelphia, PA, USA avkhera@mgh.harvard.edu rader@mail.med.upenn.edu.